Christina Applegate has returned to her podcast “MeSsy” with co-host Jamie Lynn Sigler after a seven-month break. During this time, she revealed significant news about her health. Applegate, who was previously diagnosed with multiple sclerosis (MS), shared that a recent consultation with her doctor indicated she does not have the condition.
In two new episodes released on October 20, Applegate discussed her experience with MS alongside Sigler. During her first episode back, she expressed that her doctor had confirmed she does not have MS, a revelation that was difficult for her to accept, even as others were relieved.

Dr. Marwa Kaisey, a neurologist at Cedars-Sinai Medical Center, joined Applegate and Sigler for the second episode. She explained that misdiagnoses of MS are relatively common due to the lack of a single definitive test for the disease. Dr. Kaisey pointed out that nearly 20 percent of those diagnosed with MS may not actually have it and that many of these individuals have been on treatment for years.
Applegate remarked that learning about her misdiagnosis did not alleviate her ongoing symptoms. She noted that her condition has not improved and she still struggles with health issues. She plans to work with her doctors to investigate her health challenges since 2021.
In the continuation of the podcast, Applegate spoke about the emotional toll the situation has had on her life, expressing feelings of loss related to her job and her experiences over the past six years with the condition. She mentioned her use of a wheelchair and how her daily life has been affected.
Applegate also reflected on her role in the MS community, sharing feelings of guilt about now being considered healthy when she once connected deeply with those who have the disease. She described her current state as confusing and unsettling.
Overall, Applegate summarized her health journey as dealing with the same issues, just without the label of MS. She reported that her time away from the podcast allowed her to process the new information regarding her health while managing other health-related matters.
The information in this article is not intended to replace professional medical advice or treatment. For any health concerns, it is important to consult with a healthcare provider. What are your thoughts on misdiagnoses in chronic illness?
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Source: Amo Media